This research aims to develop an Artificial Intelligence and/or multi-objective optimization based backcasting framework capable of generating holistic city redesign strategies by starting from predefined sustainability targets, such as low rate of emission, accidents, or traffic congestion. The core of the investigation involves utilizing an integrated predictive model that simultaneously addresses multi-modal transportation development and the influence on travel demand patterns (travel behaviour change) while accurately performing emission modeling for both vehicular traffic and heating sources. A core of modeling is the SUMO traffic simulation tool extended by energy, heating, emission, and demographic models. A critical objective is to incorporate the spatial and temporal impact of various urban heating systems (e.g., district heating, heat pumps) into the air quality and energy demand models, recognizing their profound influence on urban air quality and overall energy transition. As one practical example for potential research outcomes, this research will able to design the required transport infrastructure with the optimal transport modal share, or the green infrastructure to meet defined air quality and absorption targets. In all, this research seeks to provide urban planners and policymakers with a tool for creating resilient, low-carbon cities that move beyond simple forecasting to actively design desired future urban environments.